the effectiveness of luteal phase support with cyclogest in ovarian stimulated intra uterine insemination cycles: a randomized controlled trial
نویسندگان
چکیده
background: controlled ovarian stimulation combined with intra uterine insemination (iui) is a convenient treatment of infertility with a success rate of 11%. the clinical observation and pattern of progesterone secretion in this method is suggestive of luteal phase defect and postulated as an implicating factor of treatment failure. objective: to investigate the efficacy of luteal phase support with intravaginal cyclogest in women undergoing controlled ovarian stimulation combined with intrauterine insemination. materials and methods: in this single-blinded clinical trial, 196 consecutively seen women eligible for the study protocol, were randomized to receive either intravaginal progesterone (cyclogest pessary, actavis) or no medication in luteal phase. blood samples were collected and serum progesterone level in 7th and 11th day of the cycle, biochemical and clinical pregnancy and luteal phase duration were compared in case and control groups. results: the mean age in case and control group was 28 and 27.9 years, respectively and the most frequent cause of infertility was unexplained. additionally, ovulatory dysfunction was the most common cause of female infertility in both groups. based on these variables, there was no statistically significant difference between the two groups. mean serum progesterone level in the case group were 48.34 and 34.24nmol/day on day 7 and 11 after insemination, respectively and both values were significantly higher than the control group. there was no difference between the two groups in terms of biochemical and clinical pregnancy. luteal phase duration in the case group was significantly longer than the control group. conclusion: luteal phase support by cyclogest pessary increases progesterone level and prolongs the luteal phase, but does not affect success rate of iui cycles in terms of achieving pregnancy.
منابع مشابه
The effectiveness of luteal phase support with cyclogest in ovarian stimulated intra uterine insemination cycles: A randomized controlled trial
BACKGROUND Controlled ovarian stimulation combined with intra uterine insemination (IUI) is a convenient treatment of infertility with a success rate of 11%. The clinical observation and pattern of progesterone secretion in this method is suggestive of luteal phase defect and postulated as an implicating factor of treatment failure. OBJECTIVE To investigate the efficacy of luteal phase suppor...
متن کاملThe Effect of Luteal Phase Support on Pregnancy Rates of the Stimulated Intrauterine Insemination Cycles in Couples with Unexplained Infertility
Background To assess the efficacy of luteal phase support (LPS) with vaginal progesterone (P) on pregnancy rates of the stimulated intrauterine insemination (IUI) cycles in couples with unexplained infertility (UEI). MaterialsAndMethods This was a single-center, prospective, randomized, blinded control trial undertaken at a tertiary care university fertility center between October 2007 and Dece...
متن کاملluteal phase support in the intrauterine insemination (iui) cycles: a randomized double blind, placebo controlled study.
objective: to evaluate the impact of luteal phase support with vaginal progesterone on pregnancy rates in the intrauterine insemination (iui) cycles, stimulated with clomiphene citrate and human menopausal gonadotropin (hmg), in sub fertile couples. materials and methods: this prospective, randomized, double blind study was performed in a tertiary infertility center from march 2011 to january 2...
متن کاملLuteal phase support in intrauterine insemination cycles
Intrauterine insemination (IUI) treatment aims to increase the rate of conception by increasing the chances that the maximum number of healthy sperm reach the site of fertilization. IUI with controlled ovarian stimulation is frequently used in assisted reproduction practice. Although widely used, the efficacy of luteal support in IUI remains controversial. In this article, we aimed to review wh...
متن کاملLuteal Phase Support in the Intrauterine Insemination (IUI) Cycles: A Randomized Double Blind, Placebo Controlled Study
OBJECTIVE To evaluate the impact of luteal phase support with vaginal progesterone on pregnancy rates in the intrauterine insemination (IUI) cycles, stimulated with clomiphene citrate and human menopausal gonadotropin (hMG), in sub fertile couples. MATERIALS AND METHODS This prospective, randomized, double blind study was performed in a tertiary infertility center from March 2011 to January 2...
متن کاملP-54: The Effect of Luteal Phase Support onPregnancy Rate of Stimulated IUI Cycles in UnexplaiendInfertility
Background: Progesterone (P) that is produced by the corpus luteum in response to stimulation by luteinizing hormone (LH) and human Chrionic Gondotropin (hCG) in luteal phase is essential for secretory transformation of endometrium that permits implantation .P not only supports endometrial development but also potentially sustains the survival of the embryo . Luteal phase dysfunction (LPD) is a...
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عنوان ژورنال:
international journal of reproductive biomedicineجلد ۱۱، شماره ۴، صفحات ۳۰۹-۰
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